東京大学医科学研究所 感染・免疫部門 ワクチン科学分野 石井 健 研究室

MEMBERメンバー

東京大学 医科学研究所THE INSTITUTE OF MEDICAL SCIENCE, THE UNIVERSITY OF TOKYO

ワクチン科学分野VACCINE SCIENCE

教授
石井 健
准教授
小檜山 康司
特任講師
根岸 英雄
助教
Burcu Temizoz
特任研究員
林 智哉
大学院生
日置 仰, 土田 諄, 和田 雄佑, 王 程程,
原 哲平, 林 勝仁
学術支援職員
佐藤 直美
技術補佐員
山下 瑞穂
秘書
須田 涼子, 渡邉 洋子
共同研究員
大平 裕太, 鈴木 伸幸, 鈴木 啓介

医薬基盤・健康・栄養研究所NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION

モックアップワクチンプロジェクトMOCKUP VACCINE PROJECT

招へいプロジェクトリーダー
石井 健
特任研究員
小檜山 康司
協力研究員
林 智哉, Burcu Temizoz
研修生
柴原 理志, 日置 仰
共同研究員
武下 文彦, 城内 直, 戸塚 幸, 宮地 一樹, 江頭 志織


メンバーMEMBER

東京大学 医科学研究所THE INSTITUTE OF MEDICAL SCIENCE, THE UNIVERSITY OF TOKYO

石井 健

東京大学医科学研究所 感染・免疫部門 ワクチン科学分野 石井研究室

石井 健Ken J. Ishii, M.D. /Ph.D.

Curriculum VitaeKen J. Ishii, M.D. /Ph.D.

DEMOGRAPHIC INFORMATION

Personal data
Professor, Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo (IMSUT)
Director, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo (IMSUT)
Invited project leader, Laboratory of Mockup Vaccine, Center for Vaccine and Adjuvant Research (CVAR), National Institutes of Biomedical Innovation, Health and Nutrition (NBIOHN)
Guest professor, Laboratory of Vaccine Science, Immunology Frontier Research Center (IFReC), Osaka University
E-mail: kenishii@ims.u-tokyo.ac.jp
Business address
  • • Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo (IMSUT) 4-6-1 Shirokanedai, Minato-ku, Tokyo, Japan
SHORT BIO
Prof. Ken Ishii is currently a professor at Division of Vaccine Science at Department of Microbiology and Immunology at The Institute of Medical Science, The University of Tokyo (IMSUT) as well as a director at International Research and Development Center for Mucosal Vaccines at The Institute of Medical Science, The University of Tokyo (IMSUT) in Japan. Prof. Ishii graduated with a M.D and also obtained a Ph.D. from the School of Medicine, Yokohama City University, Kanagawa, Japan. He is further qualified with his years of experience in vaccine research supported by numerous book and periodical publications since 1994 including 7 years as a Visiting Scientist and IND reviewer at the Office of Vaccine Research and Review (OVRR), Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration (FDA). Based on his carreer, he conducts basic research on innate immune recognition of adjuvants and try to translate into vaccine markets in Japan.

Education history

2003 Ph.D., Graduated School of Medicine, Yokohama City University,Kanagawa, Japan
1987-1993 M.D., School of Medicine, Yokohama City University, Kanagawa, Japan

Research and career history

2019 – present Professor, Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo (IMSUT), Tokyo, Japan
2019 – present Director, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo (IMSUT), Tokyo, Japan
2017 – 2018 Director, Center for Vaccine and Adjuvant Research (CVAR), National Institutes of Biomedical Innovation,
Health and Nutrition (NBIOHN), Osaka, Japan
2010 – 2018 Project Leader, Lab. of Adjuvant Innovation, National Institutes of Biomedical Innovation, Health and Nutrition (NBIOHN), Osaka, Japan
2010 – 2018 Professor, Lab. of Vaccine Science, Immunology Frontier Research Center (IFREC), Osaka University,Osaka, Japan
2015-2017 Director, Dep. of Research Promotion, Japan Agency for Medical Research and Development (AMED),Japan
2007-2010 Associate Professor, Lab. of Host Defense, IFREC, Osaka University
2006-2010 Associate Professor, Dep. of Molecular Protozoology, Research Institute for Microbial Diseases,Osaka University, Japan
2003-2008 Director, Dep. of Research Promotion, Japan Agency for Medical Research and Development (AMED), Japan
1996-2003 Postdoc (-2000) Staff Scientist (2000-2003), IND primary reviewer (2000-2003), Office of Vaccine Research and Review (OVRR), Center for Biologics and Evaluation Research (CBER), Food and Drug
1995-1996 Anesthesiologist, Yokohama City Municipal Hospital, Kanagawa, Japan
1993-1995 Resident, School of Medicine, Yokohama City University (YCU), Kanagawa, Japan

Awards

2019 22nd Japanese Society of Immunology Award
2014 32nd Osaka Science Prize
2010 Tagata Isamu memorial vaccine research award
2008 Japanese Society of Immunology, Young Investigator Award
Selected Recent Publications
  • Kuroda E et al. Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation. Immunity, 45(6), 1299-1310 (2016).
  • Kobiyama K et al. Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist. Proc Natl Acad Sci U S A, 111(8), 3086-91 (2014).
  • Desmet C and Ishii KJ Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination. Nat Rev Immunol, 12(7), 479-91 (2012).
  • Marichal T et al. DNA released from dying host cells mediates aluminum adjuvant activity. Nat Med, 17(8), 996-1002 (2011).
  • Koyama S, et al. Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes. Sci Transl Med, 2(25), 25ra24 (2010).
  • Ishii KJ et al. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature, 451(7179), 725-9 (2008).
Books
  • Ishii KJ and Tang CK (Editor in chief) “Biological DNA Sensor: The Impact of Nucleic Acids on Diseases and Vaccinology” ELSEVIER, 2013
Guide lines
  • Guideline for Nonclinical Studies of Preventive Vaccines for Infectious Diseases issued by ministry of health, Japan. 2010. (co-PI of the project and author)
  • WHO Guidelines on the Nonclinical Evaluation of Vaccine Adjuvants and Adjuvanted Vaccines 2013 (under revision) (External advisor and author)
Editorial activities
  • Editor; Associate Editor:J.Immunol., Vaccines, Front. Immunol., NPJ Vaccines, Human Vaccine & Immunother.
  • Advisory board for EBioMedicine, Oncotarget

Education history

Professional Societies (Organizer, Director excluding membership):
2010 –present Organizer, Secretary for Japanese Consortium for Adjuvant Research
2012 –present Trustee, The Japanese Society of Vaccinology
2012 –present Councilor, Japanese Society for Immunology
2012-2015 Scientific committee, International Society of Vaccine (ISV)
2012 Organizer, 34th Naito Conference
Other activities:
2017 –present Advisor for Science and Technology, AMED, Japan
2016 Advisory Board, International Vaccine Institute, Seoul, Korea
2012-2014 Scientific advisory board, PMDA, MHLW, Japan
2008-2016 Specialty Advisor, PMDA, MHLW, Japan
2008-2010 Program Officer, MEXT Japan

RECOGNITION

Honors and Awards:
2016 Highly cited researcher 2016 (Clarivate Analytics)
2015 Highly cited researcher in Thomson Reuters 2015
2014 32th Osaka Science Prize
2014 Highly cited researcher in Thomson Reuters 2014
2012 ‘Thinking inside the box award’ DNA vaccines 2012
2010 Isamu Tagaya Memorial Vaccine Research Award
2008 Japanese Society of Immunology, Young Investigator Award
2007 ‘Rising star in Immunology’(Sep 2007) Thompson Reuter’s ISI

小檜山 康司

根岸 英雄

  • 特任講師
    東京大学 医科学研究所 感染・免疫部門 ワクチン科学分野

Burcu Temizoz

東京大学医科学研究所 感染・免疫部門 ワクチン科学分野 石井研究室

Burcu Temizoz, Ph.D.

Education

2018 Ph.D., Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan
2015 Master of Science, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan
2012 Bachelor of Molecular Biology and Genetics, Izmir Institute of Technology, Izmir, Turkey

Research and career history

2019 – present Assistant Professor, Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
2018 -2019 Specially Appointed Assistant Professor, Laboratory of Vaccine Science, Immunology Frontier Research Center (IFREC), Osaka, Japan
Selected publication
  • Lee MSJ, Natsume-Kitatani Y, Temizoz B, Fujita Y, Konishi A, Matsuda K, Igari Y, Tsukui T, Kobiyama K, Kuroda E, Onishi M, Marichal T, Ise W, Inoue T, Kurosaki T, Mizuguchi K, Akira S, Ishii KJ, Coban C. B cell-intrinsic MyD88 signaling controls IFN-γ-mediated early IgG2c class switching in mice in response to a particulate adjuvant. Eur J Immunol., doi: 10.1002/eji.201848084 (2019).
  • Temizoz B, Kuroda E, Ishii KJ. Combination and inducible adjuvants targeting nucleic acid sensors. Curr Opin Pharmacol.,doi: 10.1016/j.coph.2018.05.003 (2018).
  • Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ. Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation. Immunity,45(6), 1299-1310 (2016).
  • Kitahata Y, Kanuma T, Hayashi M, Kobayashi N, Ozasa K, Kusakabe T, Temizoz B, Kuroda E, Yamaue H, Coban C, Yamamoto T, Kobiyama K, Aoshi T, Ishii KJ. Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells. Oncotarget,7(31), 48860-48869 (2016).
  • Temizoz B, Kuroda E, Ishii KJ. Vaccine adjuvants as potential cancer immunotherapeutics. Curr Opin Pharmacol.,doi: 10.1016/j.coph.2018.05.003 (2018).
  • Kobiyama K, Temizoz B, Kanuma T, Ozasa K, Momota M, Yamamoto T, Aoshi T, Kuroda E, Ishii KJ. Species-dependent role of type I IFNs and IL-12 in the CTL response induced by humanized CpG complexed with β-glucan. Eur J Immunol.,46(5), 1142-51 (2016).
  • Temizoz B, Kuroda E, Ohata K, Jounai N, Ozasa K, Kobiyama K, Aoshi T, Ishii KJ. TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN. Eur J Immunol.,45(4), 1159-69 (2015).

林 智哉

日置 仰

土田 諄

  • 修士課程大学院生M2
    東京大学 医科学研究所 感染・免疫部門 ワクチン科学分野

和田 雄佑

  • 修士課程大学院生M2
    東京大学 医科学研究所 感染・免疫部門 ワクチン科学分野

王 程程

  • 修士課程大学院生M2
    東京大学 医科学研究所 感染・免疫部門 ワクチン科学分野
             

原 哲平

  • 修士課程大学院生M1
    東京大学 医科学研究所 感染・免疫部門 ワクチン科学分野

林 勝仁

  • 修士課程大学院生M1
    東京大学 医科学研究所 感染・免疫部門 ワクチン科学分野

大平 裕太

鈴木 伸幸

  • 共同研究員
    東京大学 医科学研究所 感染・免疫部門 ワクチン科学分野

鈴木 啓介

  • 共同研究員
    東京大学 医科学研究所 感染・免疫部門 ワクチン科学分野

佐藤 直美

  • 学術支援職員
    東京大学 医科学研究所 感染・免疫部門 ワクチン科学分野

山下 瑞穂

  • 技術補佐員
    東京大学 医科学研究所 感染・免疫部門 ワクチン科学分野

須田 涼子

  • 秘書
    東京大学 医科学研究所 感染・免疫部門 ワクチン科学分野

渡邉 洋子

  • 秘書
    東京大学 医科学研究所 感染・免疫部門 ワクチン科学分野

医薬基盤・健康・栄養研究所NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION